Vasco's Diary - Month of High Cold, 1850 is a book found in Dishonored 2.
We tested it on ourselves which we often do, in fractional doses. The night was sheer horror. It's hard to describe the effects on the mind, the frenzy it induced. We were - not ourselves. Alexandria muttered to herself, calling herself Grim Alex, almost as if she had a total shift in personality. I cannot commit to paper all that occurred, but I burn with shame remembering the way my perspective shifted, as if my entire morality was up-ended.
The following day, after recovering my senses, I felt better than I have in years. The serum might hold the keys to improved lung function and general vigor. It could even ameliorate the effects of some of our worst fevers and infections.
But the costs are too high. The absolute loss of empathy; the unfettered appetites.
And yet, a week later I watched Alexandria on the terrace below. She was in a terrible way, disheveled, with words escaping her lips that were jumbled and wild. Her movement were unfamiliar.
In the morning I asked if she had tried the serum again. She was most alarmed, assuring me that she would never again touch even a drop of it. She swears that only a sample remains, safely locked away, for future study.
The book can be found on the desk beside Vasco's safe in the Addermire Institute, during the mission The Good Doctor.