New Game + (or New Game Plus) is a game mode for Dishonored 2 introduced in Game Update 1. This mode imports all runes spent on supernatural abilities, traits of crafted bone charms and upgrades from a finished playthrough to a new one, while also giving the possibility for Corvo Attano and Emily Kaldwin to access each other's powers.
This mode is unlocked once the game is finished with at least one protagonist. Playing several New Game + playthroughs can unlock all powers, upgrades and bonecharm traits in the game without any use of file modification.
Before starting a New Game +, it is recommended to sacrifice all bonecharms to learn all availble traits, craft as many runes as possible, and spend all the runes on abilities.
Original Game +
Original Game + (or Original Game Plus), is a game mode for Dishonored: Death of the Outsider similar to New Game +. It is unlocked after finishing one playthrough of Dishonored: Death of the Outsider. In this game mode, Billie Lurk will have three of her powers (Displace, Foresight, and Semblance) replaced by fully upgraded Blink and Domino, and a modified Dark Vision (which is fully upgraded as well, but now drains mana continuously while activated, and also reveals bone charms).
Missions + (or Missions Plus) is a game mode for both Dishonored 2 and Death of the Outsider. It can be unlocked by logging in with a Bethesda.net account from the games’ main menus. The game mode allows players to replay any completed missions (except the firsts) with: all powers unlocked and upgraded; fully upgraded weapons, gadgets, gears and outfit; and all bonecharms.
In Dishonored 2, before starting a mission players can choose which protagonist to play with, the level of chaos, and which masterwork upgrades to be applied to weapons and gears. Players will also be taken directly to mission areas, skipping all the segments on the Dreadful Wale. In Death of the Outsider, Billie Lurk has access to both her supernatural powers and the ones in Original Game +, and five stun mines per mission in addition to her original gadgets.