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"She cares for the patients, treats them with compassion. Often refuses their money."
—The Heart[2]

Doctor Alexandria Hypatia is a character in Dishonored 2. She is the chief alchemist of the Addermire Institute in Karnaca and the inventor of the Addermire Solution.[3]


Hypatia was a friend of Theodanis Abele, the previous Duke of Serkonos. Recognizing her talent, Luca Abele forcibly confined her to her workplace, the Addermire Institute. Although the public was told that Hypatia did not leave Addermire in order to create a new serum against the bloodfly fever, Hypatia was in truth a prisoner of Abele.

She was renowned not just for creating the Addermire Solution but for helping the miners recover from the dangers of Karnaca's silver mines. During her efforts, Hypatia tested an early version of her serum on herself which created a split persona inside her head: Grim Alex. During the events of Dishonored 2, this process has been going on for at least three years. Hypatia was not aware of these changes, and did not fully understand why the Duke gradually restricted her to Addermire Institute, when she was perfectly willing to spend most of her time there anyway, all but abandoning her apartment above the Winslow Safe store outside Addermire Station.

Dishonored 2[]

Upon reaching the institute, Corvo Attano or Emily Kaldwin first encounter Hypatia doing her work, disoriented and exhibiting strange behavior by expressing her incorrect belief that someone is calling her. She asks to be left alone, which allows for closer inspection of the room she is working in. By either talking to a dying Doctor Bartholomeus Vasco, listening to an audiograph, possessing Hypatia, mesmerizing her or attacking her, it is revealed that she is the Crown Killer. The Crown Killer can either be killed right away, or the protagonist can follow Vasco's advice and develop a counter-serum for Hypatia's condition by finding and following the instructions for his formula.

If Hypatia's condition is cured, she is invited onboard the Dreadful Wale to recuperate. She accepts the invitation and can be found onboard after the mission, and will remain there for some time. Before she departs later on, she records an audiograph, stating that her mind has cleared and how she can now freely focus on helping those in need, lastly sending her utmost thanks for helping her.

Depending on the protagonist's choices, Hypatia can become a member of the new Duke's or Corvo's grand council in low chaos if she is saved at Addermire.

Dishonored: Death of the Outsider[]

In the months following the end of Delilah's Coup, Hypatia reopened the Addermire Institute. Realizing now the long-term side-effects of her Addermire Solution, she ceased its production. She recalled any vials still on sale and started offering health check-ups to all those who consumed the serum. By the time of Dishonored: Death of the Outsider, Addermire Solutions have been completely removed from circulation in Karnaca.


  • Alexandria Hypatia is voiced by Jessica Strauss.
  • The achievements The Beast Within and Counter-Serum can both be achieved by dealing with Hypatia. The former is earned by eliminating the Crown Killer in any fashion, the latter by talking to Hypatia aboard the Dreadful Wale, meaning she must have been cured.
  • Hypatia's doctorate was ratified by the Convocation of Etiology, approved by the Alchemical Council and validated by the Chamber of Smoke and Iron. The certificate, which stated she had passed all the requirements, including the Trials of Mineralogy and the Four Forgotten Scrutinies, was issued in Dunwall on the 28th Day, Month of Clans, 1838.
  • On the 12th Day, Month of Earth, 1847 she was awarded with the Grand Medal of Merit by the Duke of Serkonos, Theodanis Abele, for "her sustained and ingenious contributions to the field Natural Philosophy and its medical applications".
  • Her name, and to an extent, occupation, are references to Hypatia of Alexandria.[citation needed]
  • Hypatia's fame, and that of the Addermire Institute, was such that, apart from emergency cases, there was a two month wait to be able to see her.
  • If Hypatia is killed, the Grand Palace releases a statement painting her as the Crown Killer's victim.[4]
  • If Emily or Corvo attacks Hypatia before she becomes Grim Alex, she will not die, instead transforming into the Crown Killer. This remains true even for actions which would normally kill instantly, such as drop assassinations.
  • If the protagonist uses Dark Vision near Hypatia or Grim Alex in the Addermire Institute, they will see an aura surrounding her, similar to the scent detection sphere utilized by wolfhounds.