Thread:Makatak7/@comment-5174994-20121010191643/@comment-4206713-20121014150656

No, it's not game breaking, but it invalidates Clean Hands and Ghost. SPOILERS SPOILERS SPOILERS While escaping the Flooded District, if you did a side quest for both Granny Rags and Slackjaw, there will be a confrontation between them. It turns out Granny actually has supernatural abilities, is somewhat like an occultist, and captures Slackjaw and plans to cook him. She has a key that you need to progress. You can choose to help either Granny, by cooking Slackjaw, invalidating Clean Hands. Alternatively, you can refuse to help her and instead help Slackjaw. He tells you that she has a cameo of herself that makes her immortal unless it is incinerated. You must run up and burn the cameo while she is fighting you, invalidating Ghost, burn the cameo, and kill her, invalidating Clean Hands. Why don't you just knock her out? If you try before you burn the cameo, she teleports away, and if you do after you burn it it counts as a kill (which is a bug, it's not supposed to), invalidating Clean Hands. You could also help neither and just steal the key and run, but then she will see and fight you, invalidating Ghost. Also, I would feel bad if I didn't help Slackjaw.